Crossword answer
LYME
4 letters · Used for 5 different clues · 6 appearances · Last seen New York Times, September 19, 2026
Letter pattern
LYME
Clues that lead to LYME
Most recent firstClueLettersPuzzleLast seen
Connecticut town that lent its name to a tick-borne disease4New York TimesSep 19, 2026
___ disease (tick-borne disease)4Daily ThemedJul 18, 2026
Old --, Connecticut4Eugene ShefferMay 5, 2026
Tick-borne affliction, informally4New York TimesSep 11, 2025
Old —, Connecticut4Eugene ShefferAug 28, 2023
About LYME in crosswords
LYME is a 4-letter answer that has appeared 6 times in our database across 5 different clues. It was most recently the answer to “Connecticut town that lent its name to a tick-borne disease” in the New York Times crossword on September 19, 2026.
Other 4-letter answers
MIKEKaraoke gear
JABSRing exchange
FADEPale
OAHUMount Ka'ala's island
SANS___ serif, category for Arial or Helvetica
LASTThe ultimate in cataclysmal astonishment!
INCAAncient Andean
RILEReally get to
COOSDove calls
ASTOConcerning
MAINStreet that might run all the way through town
UFOS"The X-Files" topic
ETTA___ Place, female companion of Butch Cassidy and the Sundance Kid
ERIEOne of the Great Lakes
Every appearance of LYME (6)
Click to expand · newest first
Sep 19, 2026
Connecticut town that lent its name to a tick-borne disease · New York Times · 48 Down
Jul 18, 2026
___ disease (tick-borne disease) · Daily Themed · 2 Down
May 5, 2026
Old --, Connecticut · Eugene Sheffer · 11 Down
Sep 11, 2025
Tick-borne affliction, informally · New York Times · 33 Across
Aug 28, 2023
Old —, Connecticut · Eugene Sheffer · 17 Across
Jan 15, 2023
___ disease (tick-borne disease) · Daily Themed · 49 Down