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Answer:

We have spotted MULE (4 Letters) a total of 43 times in our database. Below you may see the clues associated with MULE and also when and where was it last seen:

Definition

A hybrid animal; specifically, one generated between an ass and a mare, sometimes a horse and a she-ass. See Hinny.
A plant or vegetable produced by impregnating the pistil of one species with the pollen or fecundating dust of another; -- called also hybrid.
A very stubborn person.
A machine, used in factories, for spinning cotton, wool, etc., into yarn or thread and winding it into cops; -- called also jenny and mule-jenny.

Referring crossword puzzle clues

Usage among publishers: